反应详情

Trifluoroacetic acid (3 ml) was added in one portion to a solution of 4-(4-Acryloylamino-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (1.23 g, 3.11 mmol) in DCM (6 ml). The resulting mixture was stirred at room temperature for 2 hours under a nitrogen atmosphere. After which time, the mixture was concentrated under vacuum to give the title compound (0.9 g, 98% yield) as an orange foam which was used without further purification.

1. concentrationAfter which time, the mixture was concentrated under vacuum