Thionyl Chloride → HCID 86682849, compound

HRID 1841955Notes

Reaction equation

S(Cl)([Cl:3])=O.[N+:5]([C:8]1[CH:13]=[CH:12][C:11]([S:14]([N:17]2[CH2:22][CH2:21][CH:20]([C:23]([OH:25])=O)[CH2:19][CH2:18]2)(=[O:16])=[O:15])=[CH:10][CH:9]=1)([O-:7])=[O:6]>C1(C)C=CC=CC=1>[N+:5]([C:8]1[CH:13]=[CH:12][C:11]([S:14]([N:17]2[CH2:22][CH2:21][CH:20]([C:23]([Cl:3])=[O:25])[CH2:19][CH2:18]2)(=[O:16])=[O:15])=[CH:10][CH:9]=1)([O-:7])=[O:6]

Participants

Conditions

Temperature: 80 °C

Procedure

Thionyl chloride (4.0 ml, 55.0 mmol) was added dropwise to a stirred solution of 1-(4-nitro-benzenesulfonyl)-piperidine-4-carboxylic acid (1.25 g, 3.98 mmol) in toluene (12 ml) and the mixture was heated at 80° C. for 2 hours. After this time, the reaction mixture was concentrated under vacuum to afford the title compound as a white solid which was used without further purification.

Workup

concentrationAfter this time, the reaction mixture was concentrated under vacuum

Sources & evidence

ORD record: ord-0df87de242874360a504c2c04d73646f
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08946197B2

Reaction notes

Loading…