Methyl 4-piperidineacetate → {1-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperidin-4-yl}-acetic acid

HRID 1841982Notes

Reaction equation

HRID 1841982 reaction equation
C(OC(N1C[CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C@@H:21]3[O:30][C:25]4=[N:26][CH:27]=[CH:28][CH:29]=[C:24]4[O:23][CH2:22]3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C[O:32][C:33](=[O:41])[CH2:34][CH:35]1CCNC[CH2:36]1.O1C2C(=NC=CC=2)O[C@@H](C2C=CC(CN3CCC(C(O)=O)CC3)=CC=2)C1>>[O:23]1[C:24]2[C:25](=[N:26][CH:27]=[CH:28][CH:29]=2)[O:30][C@@H:21]([C:18]2[CH:17]=[CH:16][C:15]([CH2:14][N:11]3[CH2:10][CH2:9][CH:35]([CH2:34][C:33]([OH:41])=[O:32])[CH2:36][CH2:12]3)=[CH:20][CH:19]=2)[CH2:22]1

Participants

4

Reactant 3

HCID 1515259Methyl 4-piperidineacetateHCID 683590441-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperidine-4-carboxylic acidHCID 866953624-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 86695359{1-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperidin-4-yl}-acetic acid

Procedure

The title product GG is prepared from compound GG-1 (prepared from Intermediate C and piperidin-4-yl-acetic acid methyl ester according to General Method F) according to the procedure used to synthesize Intermediate K.

Sources & evidence

ORD record
ord-25a6da96c342439fbb882debd520d210
Source dataset
uspto-grants-2015_02
Patent number
US08946203B2

Reaction notes

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