Methylamine → HCID 71736856, compound

HRID 1842001Notes

Reaction equation

HRID 1842001 reaction equation
C([O:3][C:4]([C:6]1[N:10]2[CH2:11][CH2:12][N:13]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([C@@H:22]4[O:31][C:26]5=[N:27][CH:28]=[CH:29][CH:30]=[C:25]5[O:24][CH2:23]4)=[CH:18][CH:17]=3)[CH2:14][C:9]2=[N:8][N:7]=1)=O)C.[CH3:32][NH2:33]>C(O)C>[CH3:32][NH:33][C:4]([C:6]1[N:10]2[CH2:11][CH2:12][N:13]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([C@@H:22]4[O:31][C:26]5=[N:27][CH:28]=[CH:29][CH:30]=[C:25]5[O:24][CH2:23]4)=[CH:18][CH:17]=3)[CH2:14][C:9]2=[N:8][N:7]=1)=[O:3]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 71736854HCID 71736854, compound

Product 1

HCID 71736856HCID 71736856, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The solution of compound 240 (75 mg, 0.18 mmol) in a solution of 33% methylamine in ethanol (1.0 mL) is stirred at 90° C. in a pressure tube. After 18 hours, the mixture is gradually cooled to rt. The mixture is filtered, and the solids are washed with chilled ethanol and chilled methanol then air dried to give the title product. (LC/MS method 16: ES+ m/z 407.3 [M+H]+, Rt=2.73 min)

Workup

  1. filtrationThe mixture is filtered
  2. washthe solids are washed with chilled ethanol
  3. temperaturechilled methanol
  4. customair dried

Sources & evidence

ORD record
ord-fb1b42bd6ddd4d00b0ba26ddfc0b2ac7
Source dataset
uspto-grants-2015_02
Patent number
US08946203B2

Reaction notes

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