反应详情

To 5-nitro-3-(pyridin-4-yl)-1-trityl-1H-indazoie (0.8954 g, 0.00185 mol), 10% activated palladium on carbon (0.8954 g, 1 eq by weight) was added. The reaction flask was put under vacuum, and methanol (18.5 mL) and ethyl acetate (2 mL) was added. Hydrogen gas was bubbled through the reaction for 15 minutes. The reaction was stirred at room temperature for and additional 16 h. The reaction was filtered through celite and concentrated under vacuo. The crude product (0.819 g, 95% yield) was progressed to the next step without further purification.

1. additionwas added
2. customHydrogen gas was bubbled through the reaction for 15 minutes
3. filtrationThe reaction was filtered through celite
4. concentrationconcentrated under vacuo