Hydrochloric Acid → HCID 66612619, compound

HRID 1842051Notes

Reaction equation

HRID 1842051 reaction equation
Cl.[C:2]1([CH:8]([N:10]2[CH2:15][CH2:14][CH2:13][C@H:12]([C:16]([O:18]C(C)(C)C)=[O:17])[CH2:11]2)[CH3:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)C>O1CCOCC1>[C:2]1([CH:8]([N:10]2[CH2:15][CH2:14][CH2:13][C@H:12]([C:16]([OH:18])=[O:17])[CH2:11]2)[CH3:9])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 66608970HCID 66608970, compound

Product 1

HCID 66612619HCID 66612619, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a flask, hydrochloric acid in dioxane (4M, 2 mL) was added to (3S)-tert-butyl 1-(1-phenylethyl)piperidine-3-carboxylate (0.031 g, 0.108 mmol), and the reaction was stirred for 30 minutes. Ethanol (2 mL) was added to the reaction, and the resulting solution was concentrated in vacuo. The crude product was progressed to the next step without further purification.

Workup

  1. concentrationthe resulting solution was concentrated in vacuo
  2. customThe crude product was progressed to the next step without further purification

Sources & evidence

ORD record
ord-c2611c0e385d4406bc0738174f7d92d8
Source dataset
uspto-grants-2015_02
Patent number
US08946216B2

Reaction notes

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