Hydrochloric Acid → 8-Benzyl-1,4-dioxa-8-azaspiro[4.5]decane-6-carboxylic acid

HRID 1842052Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1842052
[CH2:1]([N:8]1[CH2:17][CH2:16][C:11]2([O:15][CH2:14][CH2:13][O:12]2)[CH:10]([C:18]([O:20]CC)=[O:19])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].Cl>O>[CH2:1]([N:8]1[CH2:17][CH2:16][C:11]2([O:12][CH2:13][CH2:14][O:15]2)[CH:10]([C:18]([OH:20])=[O:19])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 22038236Ethyl 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane-6-carboxylate

Produkt 1

HCID 666136348-Benzyl-1,4-dioxa-8-azaspiro[4.5]decane-6-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

In a flask, etrahydrofuran (0.890 mL) was added to ethyl 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane-6-carboxylate (0.0813 g, 0.267 mmol). Potassium hydroxide (0.2157 g, 3.9 mmol) in water (0.445 mL) was added to the solution, and the reaction was allowed to stir for 3 hrs at 40° C. The reaction was neutralized to pH 7 using 1N hydrochloric acid. The reaction was concentrated under vacuo and purified using prep LC/MS. LC-MS: 278.65 [M+H]. LC/MS RT=1.66 min.

Aufarbeitung

  1. concentrationThe reaction was concentrated under vacuo
  2. custompurified

Quellen und Nachweise

ORD-Eintrag
ord-acfc95c6a2824f1eac82dab60519b921
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946216B2

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