反应详情

温度

40 °C

In a flask, etrahydrofuran (0.890 mL) was added to ethyl 8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane-6-carboxylate (0.0813 g, 0.267 mmol). Potassium hydroxide (0.2157 g, 3.9 mmol) in water (0.445 mL) was added to the solution, and the reaction was allowed to stir for 3 hrs at 40° C. The reaction was neutralized to pH 7 using 1N hydrochloric acid. The reaction was concentrated under vacuo and purified using prep LC/MS. LC-MS: 278.65 [M+H]. LC/MS RT=1.66 min.

1. concentrationThe reaction was concentrated under vacuo
2. custompurified