Hydrochloric Acid → HCID 57827400, compound

HRID 1842148Notes

Reaction equation

HRID 1842148 reaction equation
[OH-].[Na+].[CH2:3]([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]([C:14]([O:16]CC)=[O:15])=[N:12][CH:13]=1)=[CH2:7])[CH3:4].Cl>C(O)C>[CH2:3]([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]([C:14]([OH:16])=[O:15])=[N:12][CH:13]=1)=[CH2:7])[CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57827782HCID 57827782, compound

Product 1

HCID 57827400HCID 57827400, compoundYield 105.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 5 N sodium hydroxide solution (2 mL) was added to a solution of ethyl 5-(1-ethoxyvinyl)pyridine-2-carboxylate (100 mg) in ethanol (5 mL). The mixture was stirred at room temperature for two hours. After confirming completion of the reaction, the reaction solution was neutralized with 1 N hydrochloric acid. The aqueous layer was extracted with ethyl acetate, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain the title compound (92 mg).

Workup

  1. customcompletion of the reaction
  2. extractionThe aqueous layer was extracted with ethyl acetate
  3. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-e7f25eca79434bb39a95e86f71f5faa6
Source dataset
uspto-grants-2015_02
Patent number
US08946211B2

Reaction notes

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