HCID 57827413, compound → HCID 57827617, compound

HRID 1842165Notes

Reaction equation

HRID 1842165 reaction equation
[C:1]([NH:9][C:10]([NH:12][C@@:13]1([C:21]2[S:22][CH:23]=[C:24]([Br:26])[CH:25]=2)[CH2:18][CH2:17][O:16][CH2:15][C@H:14]1[CH2:19]O)=[S:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.Cl>[Br:26][C:24]1[CH:25]=[C:21]([C@@:13]23[N:12]=[C:10]([NH:9][C:1](=[O:8])[C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[S:11][CH2:19][C@@H:14]2[CH2:15][O:16][CH2:17][CH2:18]3)[S:22][CH:23]=1

Participants

4

Reactant 1

HCID 57827413HCID 57827413, compound

Product 1

HCID 57827617HCID 57827617, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 887MethanolSolvent

Procedure

(±)-1-Benzoyl-3-[(3R*,4S*)-4-(4-bromo-thiophen-2-yl)-3-hydroxymethyl-tetrahydro-pyran-4-yl]thiourea (233 mg) was dissolved in methanol (5 mL). Several drops of concentrated hydrochloric acid were added, followed by stirring for two hours. The reaction solution was returned to room temperature and the solvent was evaporated under reduced pressure to obtain the title compound.

Workup

  1. customwas returned to room temperature
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-1b11ac950c204e30a4c98444ff8e773a
Source dataset
uspto-grants-2015_02
Patent number
US08946211B2

Reaction notes

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