4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride → 2-Methyl-5-{2-oxo-2-[4-(2-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethylamino}-2H-pyridazin-3-one

HRID 1842363Notes

Reaction equation

HRID 1842363 reaction equation
Cl.[F:2][C:3]([F:18])([F:17])[C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[O:6][CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[CH3:19][N:20]1[C:25](=[O:26])[CH:24]=[C:23]([NH:27][CH2:28][C:29](O)=[O:30])[CH:22]=[N:21]1>>[CH3:19][N:20]1[C:25](=[O:26])[CH:24]=[C:23]([NH:27][CH2:28][C:29](=[O:30])[N:10]2[CH2:11][CH2:12][CH:7]([O:6][C:5]3[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=3[C:3]([F:2])([F:17])[F:18])[CH2:8][CH2:9]2)[CH:22]=[N:21]1

Participants

3

Procedure

Compound 19 is prepared from intermediate 1a in base form and intermediate 4h following synthesis method 2 (yield: 40%).

Workup

  1. customsynthesis method 2 (yield: 40%)

Sources & evidence

ORD record
ord-ef0a80d1dbb14732ba6c61c6194d4a6f
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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