4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride → 2-Methyl-5-{2-oxo-2-[4-(2-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethylamino}-2H-pyridazin-3-one

Participants

Role	Name	HCID	Charge
Reactant	4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride	HCID 17178004	—
Reactant	(1-Methyl-6-oxo-1,6-dihydro-pyridazin-4-ylamino)-acetic acid	HCID 68088821	—
Product	2-Methyl-5-{2-oxo-2-[4-(2-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethylamino}-2H-pyridazin-3-one	HCID 66957814	40%

Compound 19 is prepared from intermediate 1a in base form and intermediate 4h following synthesis method 2 (yield: 40%).