4-(3-(Trifluoromethyl)phenoxy)piperidine → 4-{2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2H-pyridazin-3-one

HRID 1842367Notes

Reaction equation

HRID 1842367 reaction equation
[O:1]=[C:2]1[C:7]([NH:8][CH2:9][C:10]([OH:12])=O)=[CH:6][CH:5]=[N:4][NH:3]1.[F:13][C:14]([F:29])([F:28])[C:15]1[CH:16]=[C:17]([CH:25]=[CH:26][CH:27]=1)[O:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.Cl.FC(F)(F)C1C=CC=CC=1OC1CCNCC1>>[F:29][C:14]([F:13])([F:28])[C:15]1[CH:16]=[C:17]([CH:25]=[CH:26][CH:27]=1)[O:18][CH:19]1[CH2:20][CH2:21][N:22]([C:10](=[O:12])[CH2:9][NH:8][C:7]2[C:2](=[O:1])[NH:3][N:4]=[CH:5][CH:6]=2)[CH2:23][CH2:24]1

Participants

4

Reactant 3

HCID 129995794-(3-(Trifluoromethyl)phenoxy)piperidineHCID 171780044-(2-(Trifluoromethyl)phenoxy)piperidine hydrochlorideHCID 68088351HCID 68088351, compound

Product 1

HCID 509155004-{2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2H-pyridazin-3-oneYield 36%

Procedure

Compound 44 is prepared from intermediate 7a and from 4-(3-trifluoromethyl-phenoxy)-piperidine (obtained following the method described for 1a) applying synthesis method 2 (yield: 36%).

Workup

  1. customobtained
  2. customsynthesis method 2 (yield: 36%)

Sources & evidence

ORD record
ord-a80712ef983749e3b7fed3d042d2141f
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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