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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1842367Generated: November 2, 2026

4-(3-(Trifluoromethyl)phenoxy)piperidine → 4-{2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2H-pyridazin-3-one

https://huagongshe.com/reaction/1842367

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(3-(Trifluoromethyl)phenoxy)piperidineHCID 12999579—
Reactant4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochlorideHCID 17178004—
ReactantHCID 68088351HCID 68088351—
Product4-{2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2H-pyridazin-3-oneHCID 5091550036%

Reaction Steps

Compound 44 is prepared from intermediate 7a and from 4-(3-trifluoromethyl-phenoxy)-piperidine (obtained following the method described for 1a) applying synthesis method 2 (yield: 36%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08946225B2
Source datasetuspto-grants-2015_02
ORD IDord-a80712ef983749e3b7fed3d042d2141f
Source noteuspto-grants-2015_02