4-(3-(Trifluoromethyl)phenoxy)piperidine → 4-(5-Trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

HRID 1842377Notes

Reaction equation

HRID 1842377 reaction equation
[NH2:1][C:2]1[C:3](=[O:9])[N:4]([CH3:8])[N:5]=[CH:6][CH:7]=1.[F:10][C:11]([F:26])([F:25])[C:12]1[CH:13]=[C:14]([CH:22]=[CH:23][CH:24]=1)[O:15][CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.Cl.FC(F)(F)C1C=CC=C[C:31]=1[O:32]C1CCNCC1>>[CH3:8][N:4]1[C:3](=[O:9])[C:2]([NH:1][C:31]([N:19]2[CH2:18][CH2:17][CH:16]([O:15][C:14]3[CH:13]=[C:12]([C:11]([F:10])([F:25])[F:26])[CH:24]=[CH:23][CH:22]=3)[CH2:21][CH2:20]2)=[O:32])=[CH:7][CH:6]=[N:5]1

Participants

4

Reactant 3

HCID 129995794-(3-(Trifluoromethyl)phenoxy)piperidineHCID 131036364-Amino-2-methyl-2,3-dihydropyridazin-3-oneHCID 171780044-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride

Product 1

HCID 509156754-(5-Trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amideYield 36%

Procedure

Compound 58 is prepared from intermediate 4c and from 4-(3-trifluoromethyl-phenoxy)-piperidine (obtained following the method described for intermediate 1a), applying synthesis method 7 (yield: 36%).

Workup

  1. customobtained
  2. customsynthesis method 7 (yield: 36%)

Sources & evidence

ORD record
ord-5dbf6e74dce044bea1a1c5a40e7cf14d
Source dataset
uspto-grants-2015_02
Patent number
US08946225B2

Reaction notes

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