HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-(Trifluoromethyl)phenoxy)piperidine → 4-(5-Trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-(Trifluoromethyl)phenoxy)piperidine | HCID 12999579 | — |
| Reactant | 4-Amino-2-methyl-2,3-dihydropyridazin-3-one | HCID 13103636 | — |
| Reactant | 4-(2-(Trifluoromethyl)phenoxy)piperidine hydrochloride | HCID 17178004 | — |
| Product | 4-(5-Trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide | HCID 50915675 | 36% |
Reaction Steps
Compound 58 is prepared from intermediate 4c and from 4-(3-trifluoromethyl-phenoxy)-piperidine (obtained following the method described for intermediate 1a), applying synthesis method 7 (yield: 36%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946225B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-5dbf6e74dce044bea1a1c5a40e7cf14d |
| Source note | uspto-grants-2015_02 |