2,3-Dichloropyrazine → HCID 178477898, compound

HRID 1842486Notes

Reaction equation

HRID 1842486 reaction equation
[NH:1]1[CH2:4][CH:3]([C:5]2[NH:9][C:8]3[CH:10]=[CH:11][C:12]([Cl:14])=[CH:13][C:7]=3[N:6]=2)[CH2:2]1.[Cl:15][C:16]1[C:21](Cl)=[N:20][CH:19]=[CH:18][N:17]=1>CN(C=O)C.O>[Cl:14][C:12]1[CH:11]=[CH:10][C:8]2[NH:9][C:5]([CH:3]3[CH2:4][N:1]([C:21]4[C:16]([Cl:15])=[N:17][CH:18]=[CH:19][N:20]=4)[CH2:2]3)=[N:6][C:7]=2[CH:13]=1

Participants

5

Reactant 2

HCID 785752,3-DichloropyrazineHCID 178477890HCID 178477890, compound

Product 1

HCID 178477898HCID 178477898, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2-azetidin-3-yl-5-chloro-1H-benzoimidazole (as prepared by Preparation 2) (1.0 g, 4.83 mmol) and 2,3-dichloro-pyrazine (0.71 g, 10.4 mmol) was dissolved in DMF (20 mL) and heated for 2 h at 100° C. The mixture was diluted with water (10 mL), and extracted with EtOAc (2×20 mL). The combined organic extracts were washed with water (50 mL) and brine (50 mL), dried over Na2SO4, and filtered. The filtrate was evaporated in vacuo to afford the product as a yellow solid.

Workup

  1. extractionextracted with EtOAc (2×20 mL)
  2. washThe combined organic extracts were washed with water (50 mL) and brine (50 mL)
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. customThe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-c98eb70d2e1d496e84a0211c51275797
Source dataset
uspto-grants-2015_02
Patent number
US08946230B2

Reaction notes

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