反应详情

To tert-butyl 3-(5-methyl-1H-benzo[d]imidazol-2-yl)azetidine-1-carboxylate (prepared in the previous step) was added 4 M HCl in dioxane (30 mL). The reaction mixture was stirred at RT. After 30 min, a solid coated the inside of the flask. The liquid was removed from the flask and the remaining solid was dried under high vacuum. The solid was dissolved in MeOH (20 mL) and diluted with ether (50 mL). The precipitate was collected by filtration and dried under high vacuum to give 2-(azetidin-3-yl)-5-methyl-1H-benzo[d]imidazole dihydrochloride (2.99 g, 11.5 mmol 84% yield over three steps) as a dark red solid.

1. customThe liquid was removed from the flask
2. customthe remaining solid was dried under high vacuum
3. dissolutionThe solid was dissolved in MeOH (20 mL)
4. additiondiluted with ether (50 mL)
5. filtrationThe precipitate was collected by filtration
6. customdried under high vacuum