HCID 178451787, compound → HCID 178509519, compound

HRID 1842493Notes

Reaction equation

HRID 1842493 reaction equation
[C:1]([C:3]1[CH:24]=[CH:23][C:6]2[NH:7][C:8]([CH:10]3[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]3)=[N:9][C:5]=2[CH:4]=1)#[N:2]>Cl>[NH:13]1[CH2:12][CH2:11][CH:10]([C:8]2[NH:7][C:6]3[CH:23]=[CH:24][C:3]([C:1]#[N:2])=[CH:4][C:5]=3[N:9]=2)[CH2:15][CH2:14]1

Participants

3

Reactant 1

HCID 178451787HCID 178451787, compound

Product 1

HCID 178509519HCID 178509519, compoundYield 149%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of tert-butyl 4-(5-cyano-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (6 g, 26.7 mmol) in HCl saturated MeOH (50 mL) was stirred at 60° C. for 1 h, then it was concentrated to give the crude product (9 g, 88%). The crude product was used for next step without further purification.

Workup

  1. concentrationit was concentrated

Sources & evidence

ORD record
ord-1d42ab96f9d04016ac30535fa99c6220
Source dataset
uspto-grants-2015_02
Patent number
US08946230B2

Reaction notes

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