Hydrochloric Acid → HCID 178423462, compound

HRID 1842500Notes

Reaction equation

HRID 1842500 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[NH:16][C:15]3[CH:17]=[CH:18][C:19]([CH3:21])=[CH:20][C:14]=3[N:13]=2)[CH2:9]1)=O)(C)(C)C.Cl>CO>[NH:8]1[CH2:11][CH:10]([C:12]2[NH:16][C:15]3[CH:17]=[CH:18][C:19]([CH3:21])=[CH:20][C:14]=3[N:13]=2)[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178423469HCID 178423469, compound

Product 1

HCID 178423462HCID 178423462, compoundYield 122.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

The mixture of 3-(5-methyl-1H-benzoimidazol-2-yl)-azetidine-1-carboxylic acid tert-butyl ester (1 g, 3.5 mmol) in a solution of 4M HCl in MeOH (50 mL) was stirred at 60° C. for 1 h, then it was concentrated to give the crude product (0.8 g, yield 100%). The crude product was used in the next step without further purification.

Workup

  1. concentrationit was concentrated

Sources & evidence

ORD record
ord-7004e0001d6642a0ac6d5245ec57e64f
Source dataset
uspto-grants-2015_02
Patent number
US08946230B2

Reaction notes

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