反应详情

温度

60 °C

The mixture of 3-(5-methyl-1H-benzoimidazol-2-yl)-azetidine-1-carboxylic acid tert-butyl ester (1 g, 3.5 mmol) in a solution of 4M HCl in MeOH (50 mL) was stirred at 60° C. for 1 h, then it was concentrated to give the crude product (0.8 g, yield 100%). The crude product was used in the next step without further purification.

1. concentrationit was concentrated