HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 3-chloro-N-methylpyrazine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chloropyrazine-2-carbonyl chloride | HCID 15644194 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-chloro-N-methylpyrazine-2-carboxamide | HCID 59661823 | 100% |
Reaction Steps
To a solution of 3-chloropyrazine-2-carboxylic acid chloride (350 mg, 2.0 mmol) in THF (10 mL) was added methylamine (300 mg, 10 mmol) and triethylamine (303 mg, 3.0 mmol). The reaction mixture was stirred at RT for 3 h. The reaction solution was concentrated under reduced pressure to give the desired compound (200 mg, yield 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946230B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-8a21375f261d4cafa4db3222d6d915f2 |
| Source note | uspto-grants-2015_02 |