Methylamine → 3-chloro-N-methylpyrazine-2-carboxamide

HRID 1842507Notes

Reaction equation

HRID 1842507 reaction equation
[Cl:1][C:2]1[C:3]([C:8](Cl)=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.CN.[CH2:13]([N:15](CC)CC)C>C1COCC1>[CH3:13][NH:15][C:8]([C:3]1[C:2]([Cl:1])=[N:7][CH:6]=[CH:5][N:4]=1)=[O:9]

Participants

5

Reactant 3

HCID 6329MethylamineHCID 8471TriethylamineHCID 156441943-Chloropyrazine-2-carbonyl chloride

Product 1

HCID 596618233-chloro-N-methylpyrazine-2-carboxamideYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 3-chloropyrazine-2-carboxylic acid chloride (350 mg, 2.0 mmol) in THF (10 mL) was added methylamine (300 mg, 10 mmol) and triethylamine (303 mg, 3.0 mmol). The reaction mixture was stirred at RT for 3 h. The reaction solution was concentrated under reduced pressure to give the desired compound (200 mg, yield 100%).

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8a21375f261d4cafa4db3222d6d915f2
Source dataset
uspto-grants-2015_02
Patent number
US08946230B2

Reaction notes

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