Hydrochloride methanol → HCID 67469184, compound

HRID 1842522Notes

Reaction equation

HRID 1842522 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:22].CO>>[ClH:22].[NH:8]1[CH2:9][CH:10]([C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)[CH2:11]1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 585484391,1-Dimethylethyl 3-(2-quinolinyl)-1-azetidinecarboxylate

Product 1

HCID 67469184HCID 67469184, compoundYield 100%

Procedure

A solution of 3-quinolin-2-yl-azetidine-1-carboxylic acid tert-butyl ester (2.2 g, 7.75 mmol) in 4N HCl/MeOH (20 mL) was stirred at room temperature for 30 min. The reaction mixture was concentrated to give the crude product (1.70 g, 7.75 mmol, yield 100%).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-53a987eb0ac1402a81952d1c7079b83e
Source dataset
uspto-grants-2015_02
Patent number
US08946230B2

Reaction notes

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