Dichloromethane → Methyl 4,4-difluoropyrrolidine-2-carboxylate

HRID 184254Notes

Reaction equation

HRID 184254 reaction equation
[Cl:26][CH2:27][Cl:28].[F:1][C:2]1([F:18])[CH2:3][CH:4]([C:14](=[O:15])[O:16][CH3:17])[N:5]([C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13])[CH2:6]1.[OH:19][C:20]([C:21]([F:22])([F:23])[F:24])=[O:25]>>[F:1][C:2]1([F:18])[CH2:3][CH:4]([C:14](=[O:15])[O:16][CH3:17])[NH:5][CH2:6]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 534019261000313-00-7

Product 1

HCID 18623637Methyl 4,4-difluoropyrrolidine-2-carboxylate

Sources & evidence

ORD record
ord-07e02b53abb44532be7ad5beeb5f3229
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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