反应详情

温度

60 °C

A solution of 700 mg (2.03 mmol) of methyl 2-(3-chloropyridin-2-yl)-5-methanesulphonyloxymethyl-2H-pyrazole-3-carboxylate in 15 ml of acetonitrile is admixed in succession with 336 mg (2.43 mmol) of potassium carbonate and 413 mg (2.03 mmol) of 3,5-bis(trifluoromethyl)pyrazole and the mixture is subsequently stirred at 60° C. for 1 h. After the mixture has cooled to room temperature, the solvent is concentrated on a rotary evaporator, water is added and extraction is carried out with three times 50 ml of ethyl acetate. The combined organic phases are dried over magnesium sulphate and then the solvent is removed on a rotary evaporator.

1. temperatureAfter the mixture has cooled to room temperature
2. concentrationthe solvent is concentrated on a rotary evaporator, water
3. additionis added
4. extractionextraction
5. dry with materialThe combined organic phases are dried over magnesium sulphate
6. customthe solvent is removed on a rotary evaporator