Hydrochloric Acid → HCID 66661229, compound

HRID 1842548Notes

Reaction equation

HRID 1842548 reaction equation
C(OC(=O)[NH:7][C@@H:8]([C:10]1[CH:11]=[N+:12]([O-:20])[C:13]([C:16]([F:19])([F:18])[F:17])=[CH:14][CH:15]=1)[CH3:9])(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[O-:20][N+:12]1[C:13]([C:16]([F:17])([F:18])[F:19])=[CH:14][CH:15]=[C:10]([C@H:8]([NH2:7])[CH3:9])[CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86646747HCID 86646747, compound

Product 1

HCID 66661229HCID 66661229, compoundYield 106.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl{(1R)-1-[1-oxido-6-(trifluoromethyl)-3-pyridinyl]ethyl}carbamate (140 mg, 0.457 mmol) in dioxane (2 mL) was added hydrogen chloride (4.0 M in dioxane; 0.343 mL, 1.371 mmol). The reaction mixture was stirred for 4 h. The reaction mixture was concentrated to dryness to give the hydrochloride salt of the title compound (118 mg). MS 207.1 (M+1).

Workup

  1. concentrationThe reaction mixture was concentrated to dryness

Sources & evidence

ORD record
ord-55be8d99ecb3457687e8e38b0981db8c
Source dataset
uspto-grants-2015_02
Patent number
US08946231B2

Reaction notes

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