Hydrochloric Acid → HCID 25242197, compound

HRID 1842555Notes

Reaction equation

HRID 1842555 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([NH:10]S(C(C)(C)C)=O)[CH3:9])=[N:6][CH:7]=1.Cl>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([NH2:10])[CH3:9])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66661070HCID 66661070, compound

Product 1

HCID 25242197HCID 25242197, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-[(1R)-1-(5-fluoropyridin-2-yl)ethyl]-2-methylpropane-2-sulfinamide (34.3 g, 140 mmol) in methyl alcohol (700 mL) at 0° C. was added hydrogen chloride (4.0 M in dioxane; 105 mL, 421 mmol). After 30 min, the mixture was concentrated to dryness. The residue was recrystallized using ethyl alcohol (15 mL) and ether (40 mL). The white solid was filtered and dried under reduced pressure to give the hydrochloride salt of the title compound. MS 141.1 (M+1).

Workup

  1. concentrationthe mixture was concentrated to dryness
  2. customThe residue was recrystallized
  3. filtrationThe white solid was filtered
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-832443ebd3234954a02710115e9ecdbc
Source dataset
uspto-grants-2015_02
Patent number
US08946231B2

Reaction notes

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