Bicarbonate Ion → 1-[1-(2,4-Difluorophenyl)ethyl]-3-[[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one
Reaction equation
[C:36](=[O:37])([OH:38])[O-:39].[F:1][c:2]1[c:3]([CH:9]([CH3:10])[NH:11][C:12]([C:13]([CH2:14][CH2:15][CH2:16][Cl:17])=[CH:18][c:19]2[cH:20][c:21]([F:31])[c:22](-[n:25]3[cH:26][n:27][c:28]([CH3:30])[cH:29]3)[cH:23][cH:24]2)=[O:32])[cH:4][cH:5][c:6]([F:8])[cH:7]1.[H-:33].[Na+:34].[Na+:40].[O:41]=[CH:42][N:43]([CH3:44])[CH3:45].[OH2:35]>>[F:1][c:2]1[c:3]([CH:9]([CH3:10])[N:11]2[C:12](=[O:32])[C:13](=[CH:18][c:19]3[cH:20][c:21]([F:31])[c:22](-[n:25]4[cH:26][n:27][c:28]([CH3:30])[cH:29]4)[cH:23][cH:24]3)[CH2:14][CH2:15][CH2:16]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-88e81488536740a782bccda818c8b363
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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