HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(3-fluoro-4-nitrophenyl)propanoate → Ethyl 2-(4-amino-3-fluorophenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(3-fluoro-4-nitrophenyl)propanoate | HCID 12879863 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(4-amino-3-fluorophenyl)propanoate | HCID 20364696 | 88.1% |
Reaction Steps
A suspension of ethyl 2-(3-fluoro-4-nitrophenyl)propanoate (8.3 g, 34.41 mmol) and Pd/C (10% Pd) in EtOH (170 mL) was hydrogenated for 1 h under a hydrogen atmosphere (2.5 bar, 22° C.). The suspension was removed by filtration, concentrated under vacuum and purified by column chromatography (SiO2, ethyl acetate/hexane 1:5) to obtain ethyl 2-(4-amino-3-fluorophenyl)propanoate (6.4 g, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946204B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-96858443ecac40b7801ca285f9207708 |
| Source note | uspto-grants-2015_02 |