反应详情

A suspension of ethyl 2-(3-fluoro-4-nitrophenyl)propanoate (8.3 g, 34.41 mmol) and Pd/C (10% Pd) in EtOH (170 mL) was hydrogenated for 1 h under a hydrogen atmosphere (2.5 bar, 22° C.). The suspension was removed by filtration, concentrated under vacuum and purified by column chromatography (SiO2, ethyl acetate/hexane 1:5) to obtain ethyl 2-(4-amino-3-fluorophenyl)propanoate (6.4 g, 77%).

1. custom(2.5 bar, 22° C.)
2. customThe suspension was removed by filtration
3. concentrationconcentrated under vacuum
4. custompurified by column chromatography (SiO2, ethyl acetate/hexane 1:5)