反应详情

To a solution of methyl 2-(3-fluoro-4-(methylsulfonyl)phenyl)propanoate (2.1 g, 0.008 mol) in methanol (21 mL, 10 times), a solution of sodium hydroxide (0.32 g, 1 eq) in water (3 mL) was added at 0° C. The contents were allowed to come to room temperature and the mixture was stirred for 2 h. Progress of the reaction was monitored by TLC (50% ethyl acetate/hexane, Rf˜0.1). On completion of the reaction, methanol was distilled off completely and the residue obtained was taken in water. The contents were acidified to a pH of 4 with diluted HCl, the precipitate was filtered and dried to yield 2-(3-fluoro-4-(methylsulfonyl)phenyl)propanoic acid as a white colored solid (1.7 g, 85%).

1. customto come to room temperature
2. distillationwas distilled off completely
3. customthe residue obtained
4. filtrationthe precipitate was filtered
5. customdried