反应详情

温度

70 °C

To a stirred solution of 1-(2-bromoethyl)-2-fluoro-4-nitrobenzene (1 g, 4.03 mmol) in isopropanol (15 mL) was added sodium methane sulfinate (2.05 g, 20.16 mmol) at room temperature. The reaction mixture was heated to 70° C. for 10 h. The reaction mixture was cooled to room temperature and was concentrated under reduced pressure to obtain a crude compound which was filtered out and the residue was washed with water (2×5 mL) to obtain pure 2-fluoro-1-(2-(methylsulfonyl)ethyl)-4-nitrobenzene (700 mg, 70%).

1. temperatureThe reaction mixture was cooled to room temperature
2. concentrationwas concentrated under reduced pressure
3. customto obtain a crude compound which
4. filtrationwas filtered out
5. washthe residue was washed with water (2×5 mL)