2,2,2-Trifluoroethanol → HCID 46219668, compound

HRID 1843062Notes

Reaction equation

HRID 1843062 reaction equation
ClC1C=CC(NC(C2C(C(F)(F)F)=CC([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])=CN=2)=O)=CC=1C(=O)NC1CC1.Cl[C:34]1[CH:39]=[C:38]([C:40]([F:43])([F:42])[F:41])[C:37]([C:44]([NH:46][C:47]2[CH:52]=[CH:51][C:50]([Cl:53])=[C:49]([C:54](=[O:59])[NH:55][CH:56]3[CH2:58][CH2:57]3)[CH:48]=2)=[O:45])=[CH:36][N:35]=1.FC(F)(F)CO>>[Cl:53][C:50]1[CH:51]=[CH:52][C:47]([NH:46][C:44]([C:37]2[CH:36]=[N:35][C:34]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[CH:39][C:38]=2[C:40]([F:43])([F:42])[F:41])=[O:45])=[CH:48][C:49]=1[C:54](=[O:59])[NH:55][CH:56]1[CH2:58][CH2:57]1

Participants

4

Reactant 3

HCID 64092,2,2-TrifluoroethanolHCID 58542533HCID 58542533, compoundHCID 86660087HCID 86660087, compound

Product 1

HCID 46219668HCID 46219668, compound

Procedure

Analogously to the preparation of (Ib-2), N-[4-chloro-3-(cyclopropylcarbamoyl)phenyl]-5-(2,2,2-trifluoroethoxy)-3-(trifluoromethyl)pyridine-2-carboxamide is synthesized from 2-chloro-N-[4-chloro-3-(cyclopropylcarbamoyl)phenyl]-4-(trifluoromethyl)pyridine-5-carboxamide and 2,2,2-trifluoroethanol.

Sources & evidence

ORD record
ord-449ec54815ca487fa232937efaf33e38
Source dataset
uspto-grants-2015_02
Patent number
US08946234B2

Reaction notes

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