Dichloromethane → 4-(4-Iodo-phenyl)-piperidine-4-carbonitrile

HRID 184323Notes

Reaction equation

HRID 184323 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][cH:16][c:17]([I:20])[cH:18][cH:19]2)([C:21]#[N:22])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:30][CH2:31][Cl:32].[F:23][C:24]([F:25])([F:26])[C:27]([OH:28])=[O:29]>>[NH:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][cH:16][c:17]([I:20])[cH:18][cH:19]2)([C:21]#[N:22])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 207794754-Cyano-4-(4-iodo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 224903724-(4-Iodo-phenyl)-piperidine-4-carbonitrile

Sources & evidence

ORD record
ord-f98ee0f37adf45f5a03bb289a9248056
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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