HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | Methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate | HCID 66705783 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | Methyl 3-[(6-hydroxy-1-methyl-1H-benzimidazol-2-yl)methoxy]benzoate | HCID 56933238 | — |
Reaction Steps
Methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate produced in Example (1d) (296 g, 538 mmol), a 4 M hydrochloric acid/1,4-dioxane solution (500 mL) and 1,4-dioxane (500 mL) was stirred at 60° C. for two hours. After leaving to cool, the precipitated solid was collected by filtration to obtain a hydrochloride of the title compound as a gray solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946264B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-46b53c256f334881b7bb940ad6f48f53 |
| Source note | uspto-grants-2015_02 |