反应详情

Methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate produced in Example (1d) (296 g, 538 mmol), a 4 M hydrochloric acid/1,4-dioxane solution (500 mL) and 1,4-dioxane (500 mL) was stirred at 60° C. for two hours. After leaving to cool, the precipitated solid was collected by filtration to obtain a hydrochloride of the title compound as a gray solid.

1. customAfter leaving
2. temperatureto cool
3. filtrationthe precipitated solid was collected by filtration