1,4-Dioxane hydrochloride → Hydrochloric Acid

HRID 1843691Notes

Reaction equation

HRID 1843691 reaction equation
C(O[C:6]([N:8](C)[C:9]1[CH:14]=[C:13]([O:15]CC2C=CC(OC)=CC=2)[CH:12]=[CH:11][C:10]=1[NH:25][C:26](=O)[CH2:27][O:28][C:29]1[CH:30]=[C:31]([CH:36]=[CH:37][CH:38]=1)[C:32]([O:34][CH3:35])=[O:33])=O)(C)(C)C.[ClH:41].O1CCOCC1>O1CCOCC1>[ClH:41].[OH:15][C:13]1[CH:12]=[CH:11][C:10]2[N:25]=[C:26]([CH2:27][O:28][C:29]3[CH:30]=[C:31]([CH:36]=[CH:37][CH:38]=3)[C:32]([O:34][CH3:35])=[O:33])[N:8]([CH3:6])[C:9]=2[CH:14]=1

Participants

5

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 66705783Methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate

Product 2

HCID 313Hydrochloric AcidHCID 56933238Methyl 3-[(6-hydroxy-1-methyl-1H-benzimidazol-2-yl)methoxy]benzoate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Methyl 3-[2-({2-[(tert-butoxycarbonyl)(methyl)amino]-4-[(4-methoxybenzyl)oxy]phenyl}amino)-2-oxoethoxy]benzoate produced in Example (1d) (296 g, 538 mmol), a 4 M hydrochloric acid/1,4-dioxane solution (500 mL) and 1,4-dioxane (500 mL) was stirred at 60° C. for two hours. After leaving to cool, the precipitated solid was collected by filtration to obtain a hydrochloride of the title compound as a gray solid.

Workup

  1. customAfter leaving
  2. temperatureto cool
  3. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-46b53c256f334881b7bb940ad6f48f53
Source dataset
uspto-grants-2015_02
Patent number
US08946264B2

Reaction notes

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