Water → HCID 66705731, compound

HRID 1843711Notes

Reaction equation

HRID 1843711 reaction equation
[Br:1][C:2]1[C:3]([O:10][C:11]2[CH:12]=[CH:13][C:14]3[N:18]=[C:17]([CH2:19][O:20][C:21]4[CH:22]=[C:23]([CH:28]=[CH:29][CH:30]=4)[C:24]([O:26][CH3:27])=[O:25])[N:16]([CH3:31])[C:15]=3[CH:32]=2)=[N:4][CH:5]=[C:6]([Br:9])[C:7]=1Cl.[CH3:33][O-:34].[Na+].O>CO>[Br:1][C:2]1[C:3]([O:10][C:11]2[CH:12]=[CH:13][C:14]3[N:18]=[C:17]([CH2:19][O:20][C:21]4[CH:22]=[C:23]([CH:28]=[CH:29][CH:30]=4)[C:24]([O:26][CH3:27])=[O:25])[N:16]([CH3:31])[C:15]=3[CH:32]=2)=[N:4][CH:5]=[C:6]([Br:9])[C:7]=1[O:34][CH3:33]

Participants

5

Reactant 3

HCID 962WaterHCID 10942334Sodium MethoxideHCID 66705777Methyl 3-[[6-[(3,5-dibromo-4-chloro-2-pyridinyl)oxy]-1-methyl-1H-benzimidazol-2-yl]methoxy]benzoate

Product 1

HCID 66705731HCID 66705731, compoundYield 8.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction and post-treatment were carried out according to Example (3b) using methyl 3-({6-[(3,5-dibromo-4-chloropyridin-2-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoate produced in Example (14c) (1.56 g, 2.68 mmol), sodium methoxide (5.0 M solution in methanol, 5.36 mL, 26.8 mmol), water (5 mL) and methanol (100 mL) to obtain the title compound (0.13 g, 8%) as a white solid.

Workup

  1. customThe reaction

Sources & evidence

ORD record
ord-ed176af7a4b94b0b8ac8adc5d3a5b2cd
Source dataset
uspto-grants-2015_02
Patent number
US08946264B2

Reaction notes

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