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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1843711Generated: November 3, 2026

Water → HCID 66705731, compound

https://huagongshe.com/reaction/1843711

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantSodium MethoxideHCID 10942334—
ReactantMethyl 3-[[6-[(3,5-dibromo-4-chloro-2-pyridinyl)oxy]-1-methyl-1H-benzimidazol-2-yl]methoxy]benzoateHCID 66705777—
SolventMethanolHCID 887—
ProductHCID 66705731HCID 667057318.4%

Reaction Steps

The reaction and post-treatment were carried out according to Example (3b) using methyl 3-({6-[(3,5-dibromo-4-chloropyridin-2-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoate produced in Example (14c) (1.56 g, 2.68 mmol), sodium methoxide (5.0 M solution in methanol, 5.36 mL, 26.8 mmol), water (5 mL) and methanol (100 mL) to obtain the title compound (0.13 g, 8%) as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08946264B2
Source datasetuspto-grants-2015_02
ORD IDord-ed176af7a4b94b0b8ac8adc5d3a5b2cd
Source noteuspto-grants-2015_02