Pyridine, hydrofluoride (1:1) → HCID 86661627, compound

HRID 1843712Notes

Reaction equation

HRID 1843712 reaction equation
[Br:1][C:2]1[C:3](N)=[N:4][C:5]([Br:9])=[C:6]([Br:8])[CH:7]=1.N([O-])=O.[Na+].N1C=CC=CC=1.[FH:21]>>[Br:9][C:5]1[C:6]([Br:8])=[CH:7][C:2]([Br:1])=[C:3]([F:21])[N:4]=1

Participants

4

Reactant 3

HCID 64774Pyridine, hydrofluoride (1:1)HCID 36083823,5,6-tribromopyridin-2-amineHCID 23668193Sodium Nitrite

Product 1

HCID 86661627HCID 86661627, compoundYield 84%

Procedure

The reaction and post-treatment were carried out according to Example (8a) using 3,5,6-tribromopyridin-2-amine produced in Example (15a) (2.34 g, 7.07 mmol), sodium nitrite (0.73 g, 10.6 mmol) and hydrogen fluoride-pyridine (5 mL) to obtain the title compound (1.98 g, 84%) as a pale yellow oil.

Workup

  1. customThe reaction

Sources & evidence

ORD record
ord-ac9acbac02114da3af6a4786bfb17773
Source dataset
uspto-grants-2015_02
Patent number
US08946264B2

Reaction notes

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