Methyl 3-[2-({4-[(2-methoxy-6-methylpyridin-4-yl)oxy]-2-(methylamino)phenyl}amino)-2-oxoethoxy]benzoate → Methyl 3-({6-[(2-Methoxy-6-methylpyridin-4-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoate

HRID 1843723Notes

Reaction equation

HRID 1843723 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17](=O)[CH2:18][O:19][C:20]3[CH:21]=[C:22]([CH:27]=[CH:28][CH:29]=3)[C:23]([O:25][CH3:26])=[O:24])=[C:12]([NH:31][CH3:32])[CH:11]=2)[CH:6]=[C:5]([CH3:33])[N:4]=1>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]3[N:16]=[C:17]([CH2:18][O:19][C:20]4[CH:21]=[C:22]([CH:27]=[CH:28][CH:29]=4)[C:23]([O:25][CH3:26])=[O:24])[N:31]([CH3:32])[C:12]=3[CH:11]=2)[CH:6]=[C:5]([CH3:33])[N:4]=1

Participants

3

Reactant 1

HCID 66705876Methyl 3-[2-({4-[(2-methoxy-6-methylpyridin-4-yl)oxy]-2-(methylamino)phenyl}amino)-2-oxoethoxy]benzoate

Product 1

HCID 66705839Methyl 3-({6-[(2-Methoxy-6-methylpyridin-4-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoateYield 99%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The reaction and post-treatment were carried out according to Example (16f) using methyl 3-[2-({4-[(2-methoxy-6-methylpyridin-4-yl)oxy]-2-(methylamino)phenyl}amino)-2-oxoethoxy]benzoate produced in Example (17d) (4.44 g, 9.83 mmol) and acetic acid (50 mL) to obtain the title compound (4.12 g, 99%) as a white powder.

Workup

  1. customThe reaction

Sources & evidence

ORD record
ord-de964484223f475788245312463b1839
Source dataset
uspto-grants-2015_02
Patent number
US08946264B2

Reaction notes

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