反应详情

Chloro ethyl formate (1.92 mL) and 2N Na2CO3 solution (20 mL) were added to a stirred solution of 2-(4-chloro-phenyl)-ethylamine (I-1b: 2.6 g, 0.01667 mmol) in chloroform (20 mL). The resulting mixture was stirred at room temperature for 3 hours. The reaction was monitored by TLC (20% ethylacetate in hexane). The reaction mixture was partitioned between water and chloroform. The organic layer was washed with water, brine solution, dried over Na2SO4 and concentrated under reduced pressure. Purification by column chromatography on silica gel (10% ethylacetate in hexane) afforded 2 g of the product (52.6% yield).

1. customThe reaction mixture was partitioned between water and chloroform
2. washThe organic layer was washed with water, brine solution
3. dry with materialdried over Na2SO4
4. concentrationconcentrated under reduced pressure
5. customPurification by column chromatography on silica gel (10% ethylacetate in hexane)