反应详情

温度

110 °C

Using an analogous procedure and workup as described in Example 1, (2-thiophen-3-yl-ethyl)-carbamic acid ethyl ester (I-5c: 1.1 g, 5.527 mmol) in POCl3 (10 mL) was reacted with P2O5 (1.6 g, 11.05 mmol). The resulting mixture was stirred at 110° C. for 3 hours to afford the crude product. Purification by column chromatography on silica gel (1.5% methanol in DCM) afforded 280 mg of the product (33.13% yield).

1. customto afford the crude product
2. customPurification by column chromatography on silica gel (1.5% methanol in DCM)