2-Naphthalenecarboxaldehyde → HCID 269865, compound

HRID 1843839Notes

Reaction equation

HRID 1843839 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=O.[N+:13]([CH3:16])([O-:15])=[O:14].[OH-].[Na+]>C(O)C>[N+:13]([CH:16]=[CH:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)([O-:15])=[O:14]

Participants

5

Reactant 3

HCID 62012-NaphthalenecarboxaldehydeHCID 6375NitromethaneHCID 14798Sodium Hydroxide

Product 1

HCID 269865HCID 269865, compoundYield 84.21%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

Using an analogous reaction procedure and workup as described in Example 1, step 1, naphthalene-2-carbaldehyde (3 g, 19.20 mmol) in ethanol (35 mL) was reacted with nitro methane (1.17 g, 19.49 mmol) and 10N NaOH (0.807 g, 20.17 mmol). The resulting mixture was stirred at 0° C. for 1 hour to afford 3.2 g of the product (84.21% yield).

Workup

  1. customan analogous reaction procedure

Sources & evidence

ORD record
ord-fca2c5d47715447297a74fe95e2903e6
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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