Potassium Cation → 3-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}oxazolidin-2-one

HRID 184387Notes

Reaction equation

HRID 184387 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:25])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:14]([c:17]3[n:18][cH:19][c:20]([CH3:24])[cH:21][c:22]3[CH3:23])[CH2:15][CH2:16]2)[c:6]([F:8])[cH:7]1.[C:32](=[O:33])([O-:34])[O-:35].[CH3:38][NH:39][CH2:40][CH2:41][NH:42][CH3:43].[CH3:47][c:48]1[cH:49][cH:50][cH:51][cH:52][cH:53]1.[Cu:44][I:45].[K+:36].[K+:37].[O:26]1[C:27](=[O:31])[NH:28][CH2:29][CH2:30]1.[OH2:46]>>[c:2]1([N:28]2[C:27](=[O:31])[O:26][CH2:30][CH2:29]2)[cH:3][c:4]([F:25])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:14]([c:17]3[n:18][cH:19][c:20]([CH3:24])[cH:21][c:22]3[CH3:23])[CH2:15][CH2:16]2)[c:6]([F:8])[cH:7]1

Participants

9

Reactant 8

HCID 813Potassium Cation2×HCID 962WaterHCID 1140TolueneHCID 8070N,N'-DimethylethylenediamineHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 739492-OxazolidinoneHCID 58484761(4-Bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 673808853-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}oxazolidin-2-one

Sources & evidence

ORD record
ord-688b63c25ed34d7d90cfb39030761282
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…