Phosphorus oxide (P4O10) → HCID 66807312, compound

Participants

Reaction Steps

Using the same procedure and workup as described in Example 1, step 4, [2-methyl-2-(4-trifluoromethyl-phenyl)-propyl]-carbamic acid ethyl ester (I-20c: 1.1 g, 3.8062 mmol) in POCl3 (8 mL) was reacted with P2O5 (1.08 g, 7.6162 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.5% methanol in DCM) afforded 360 mg of the product (33.3% yield).

Provenance & Evidence