Phosphorus oxide (P4O10) → HCID 66807312, compound

HRID 1843873Notes

Reaction equation

HRID 1843873 reaction equation
C([O:3][C:4](=O)[NH:5][CH2:6][C:7]([CH3:19])([C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)[CH3:8])C.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>O=P(Cl)(Cl)Cl>[CH3:8][C:7]1([CH3:19])[C:9]2[C:14](=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[C:4](=[O:3])[NH:5][CH2:6]1

Participants

4

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 89970264HCID 89970264, compound

Product 1

HCID 66807312HCID 66807312, compoundYield 38.9%

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideSolvent

Procedure

Using the same procedure and workup as described in Example 1, step 4, [2-methyl-2-(4-trifluoromethyl-phenyl)-propyl]-carbamic acid ethyl ester (I-20c: 1.1 g, 3.8062 mmol) in POCl3 (8 mL) was reacted with P2O5 (1.08 g, 7.6162 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.5% methanol in DCM) afforded 360 mg of the product (33.3% yield).

Workup

  1. customto afford the crude product
  2. customPurification by column chromatography on silica gel (1.5% methanol in DCM)

Sources & evidence

ORD record
ord-5019865df53b4c6bb8bd64f04f81dc72
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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