HCID 66801648, compound → HCID 66803579, compound

HRID 1843886Notes

Reaction equation

HRID 1843886 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][C:12]([N+:18]([O-])=O)=[CH:13][CH:14]=2)[C:9]1=[O:21]>CO.C(O)(=O)C.[Pd]>[NH2:18][C:12]1[CH:11]=[C:10]2[C:15]([CH2:16][CH2:17][N:8]([C:3]3[CH:4]=[N:5][CH:6]=[CH:7][C:2]=3[CH3:1])[C:9]2=[O:21])=[CH:14][CH:13]=1

Participants

5

Reactant 1

HCID 66801648HCID 66801648, compound

Product 1

HCID 66803579HCID 66803579, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolventHCID 887MethanolSolvent

Procedure

Using analogous reaction conditions as described in Example 24, 2-(4-methyl-pyridin-3-yl)-7-nitro-2H-isoquinolin-1-one (I-24b: 120 mg, 0.4240 mmol) in methanol (10 mL) and acetic acid (0.1 mL) was reduced using Pd/C (40 mg) at 50 PSI in a Parr hydrogenator at room temperature for 3.30 hours.

Workup

  1. customreaction conditions
  2. customat room temperature
  3. customfor 3.30 hours

Sources & evidence

ORD record
ord-fff20d3b79af4f10b655bf50d8bc80cd
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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