反应详情

Using analogous reaction conditions as described in Example 1, 7-methoxy-3,4-dihydro-2H-isoquinolin-1-one (I-26b: 400 mg, 2.259 mmol) was reacted with 3-iodo-4-methyl-pyridine (495 mg, 2.259 mmol), 1,4-dioxane (25 mL), copper iodide (43 mg, 0.225 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (96.23 mg, 0.677 mmol) and potassium phosphate (1.197 g, 5.647 mmol) to afford the crude product. Purification by column chromatography on silica gel (40% ethylacetate in hexane) afforded 170 mg of the product (23% yield).

1. customreaction conditions
2. customto afford the crude product
3. customPurification by column chromatography on silica gel (40% ethylacetate in hexane)