HCID 66804016, compound → HCID 66803579, compound

HRID 1843897Notes

Reaction equation

HRID 1843897 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([N+:18]([O-])=O)=[CH:13][CH:14]=2)[C:9]1=[O:21]>CO.[Pd]>[NH2:18][C:12]1[CH:11]=[C:10]2[C:15]([CH2:16][CH2:17][N:8]([C:3]3[CH:4]=[N:5][CH:6]=[CH:7][C:2]=3[CH3:1])[C:9]2=[O:21])=[CH:14][CH:13]=1

Participants

4

Reactant 1

HCID 66804016HCID 66804016, compound

Product 1

HCID 66803579HCID 66803579, compoundYield 82.02%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Using analogous reaction conditions as described in Example 25, 2-(4-methyl-pyridin-3-yl)-7-nitro-3,4-dihydro-2H-isoquinolin-1-one (I-30a: 150 mg, 0.53 mmol) in methanol (100 mL) was reacted with 10% Pd/C (30 mg) to afford 110 mg of the product (82.02% yield).

Workup

  1. customreaction conditions

Sources & evidence

ORD record
ord-97742715fb084b5892b538b5589cfe89
Source dataset
uspto-grants-2015_02
Patent number
US08946260B2

Reaction notes

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