Nitromethane → 1-Chloro-2-fluoro-4-(2-nitro-vinyl)-benzene

HRID 1843903노트

반응식

HRID 1843903 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[F:10].[N+:11]([CH3:14])([O-:13])=[O:12].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:14][N+:11]([O-:13])=[O:12])=[CH:4][C:3]=1[F:10]

참가 물질

5

반응물 3

HCID 6375NitromethaneHCID 14798Sodium HydroxideHCID 27249854-Chloro-3-Fluorobenzaldehyde

생성물 1

HCID 668017121-Chloro-2-fluoro-4-(2-nitro-vinyl)-benzene수율 44%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Using the same reaction procedure and workup as described in Example 1, 4-chloro-3-fluoro-benzaldehyde (2 g, 12.61 mmol) in ethanol (20 mL) was reacted with nitro methane (0.7 mL, 12.61 mmol), 10N NaOH solution (529 mg, 12.61 mmol) at 0° C. for 2 hours to afford 1.1 g of the product (44% yield).

후처리

  1. customthe same reaction procedure

출처 및 근거

ORD 기록
ord-699e6e9e7402467a9b2944ab75d8fb7e
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946260B2

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