反应详情

Using analogous reaction conditions as described in Example 1, 7-methoxy-3,4-dihydro-2H-isoquinolin-1-one (I-35b: 1 g, 5.64 mmol) was reacted with 3-iodo-4-methyl-pyridine (1.237 g, 5.64 mmol), 1,4-dioxane (300 mL), copper iodide (107.4 mg, 0.564 mmol), trans-N,N′-dimethyl-cyclohexyl-1,2-diamine (240.2 mg, 1.69 mmol) and potassium phosphate (2.98 g, 141 mmol) to afford the crude product. Purification by column chromatography on silica gel (40% ethylacetate in hexane) afforded 850 mg of the product (56% yield).

1. customreaction conditions
2. customto afford the crude product
3. customPurification by column chromatography on silica gel (40% ethylacetate in hexane)